Dietary Soy Isoflavones Inhibit Estrogen Effects in the Postmenopausal Breast
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چکیده
منابع مشابه
Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast.
Soy isoflavones are promising dietary agents for prevention of breast cancer. Isoflavones bind estrogen receptors (ER) and may variably act as either estrogen agonists or antagonists depending on the estrogen environment. In this study, we used a postmenopausal primate model to evaluate interactive effects of dietary soy isoflavones and estrogen on risk markers for breast cancer. The experiment...
متن کاملSoy isoflavones and breast cancer.
The soybean and its products have been a staple in the Asian diet for centuries. Although intake of soy remains low in most Western populations, the use of soy isoflavone supplements has become commonplace, and an increasing number of food products contain soy ingredients. This review will present an updated summary of the observational results on soy isoflavones and risk of breast cancer devel...
متن کاملPast oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis).
Estrogen metabolism may play an important role in mammary carcinogenesis in postmenopausal women. We evaluated the effects of prior oral contraceptive (OC) treatment and current soy isoflavone consumption on endogenous estrogen metabolite concentration and biomarkers of tissue estrogen exposure in a monkey model. One hundred eighty-one female cynomolgus macaques were randomized to receive OC or...
متن کاملSoy Isoflavones and Breast Cancer
Introduction It has been recognized for several decades that the use of legumes in traditional eastern diets has played a significant role in the incidence and mortality of certain disease states. Soy beans and products containing soy possess unique phytochemicals known as isoflavones which are thought to exert many biological effects in the human body. Scientists have proposed that these uniqu...
متن کاملSoy foods, isoflavones, and the health of postmenopausal women.
Over the past 2 decades, soy foods have been the subject of a vast amount of research, primarily because they are uniquely rich sources of isoflavones. Isoflavones are classified as both phytoestrogens and selective estrogen receptor modulators. The phytoestrogenic effects of isoflavones have led some to view soy foods and isoflavone supplements as alternatives to conventional hormone therapy. ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2006
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-05-2067